Ac-YVAD-CHO | Ac-Tyr-Val-Ala-Asp-H

Ac-YVAD-CHO | Ac-Tyr-Val-Ala-Asp-H

148,00  excl. 19% VAT

SKU: 3165-v Category: Tags: ,

Ac-YVAD-CHO | Ac-Tyr-Val-Ala-Asp-H (aldehyde)

3165-v 5 mg | 148.00 EUR

Acetyl- L-tyrosyl- L-valyl- L-alanyl- L- aspart-1-al

(M.W. 492.53) C23H32N4O8 [143313-51-3]

Synthetic Product

Specific, reversible Inhibitor for Caspase-1

The tetrapeptide aldehyd Ac-YVAD-CHO is a reversible inhibitor for caspase-1 and is often used as a control substance for enzyme inhibition. This inhibitor is also used to block IL-18 production. Ac-YVAD-CHO inhibits ICE, interleukin-1β converting enzyme reversible, whereas Ac-YVAD-CMK binds irreversible at the same target. The less specific z-vad-fmk is also available as well as the fluorogenic enzyme substrate Ac-YVAD-AMC


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  2. S.M. Molineaux, F.J. Casano, A.M. Rolando, E.P. Peterson, G. Limjuco, J. Chin, P.R. Griffin, J.R. Calaycay, G.J.-F. Ding, T.-T. Yamin, O.C. Palyha, S. Luell, D. Fletcher, D.K. Miller, A.D. Howard, N.A. Thornberry and M.J. Kostura, Proc. Natl. Acad. Sci. USA, 90, 1809 (1993)