Ac-YVAD-CHO | Ac-Tyr-Val-Ala-Asp-H

Ac-YVAD-CHO | Ac-Tyr-Val-Ala-Asp-H

152,00  excl. 19% VAT

SKU: 3165-v Category: Tags: ,

Ac-YVAD-CHO | Ac-Tyr-Val-Ala-Asp-H (aldehyde)

3165-v 5 mg | 152.00 EUR

Acetyl- L-tyrosyl- L-valyl- L-alanyl- L- aspart-1-al

(M.W. 492.53) C23H32N4O8 [143313-51-3]

Synthetic Product

Specific, reversible Inhibitor for Caspase-1

The tetrapeptide aldehyd Ac-YVAD-CHO is a reversible inhibitor for caspase-1 and is often used as a control substance for enzyme inhibition. This inhibitor is also used to block IL-18 production. Ac-YVAD-CHO inhibits ICE, interleukin-1β converting enzyme reversible, whereas Ac-YVAD-CMK binds irreversible at the same target. The less specific z-vad-fmk is also available by PeptaNova as well as the fluorogenic enzyme substrate Ac-YVAD-AMC.
All these commonly used caspase substrates and inhibitors are available from our stock in Sandhausen, Germany.


  1. N.A. Thornberry, H.G. Bull, J.R. Calaycay, K.T. Chapman, A.D. Howard, M.J. Kostura, D.K. Miller, S.M. Molineaux, J.R. Weidner, J. Aunins, K.O. Elliston, J.M. Ayala, F.J. Casano, J. Chin, G.J.-F. Ding, L.A. Egger, E.P. Gaffney, G. Limjuco, O.C. Palyha, S.M. Raju, A.M. Rolando, J.P. Salley, T.-T. Yamin, T.D. Lee, J.E. Shively, M. MacCross, R.A. Mumford, J.A. Schmidt and M.J. Tocci, Nature, 356, 368 (1992)
  2. S.M. Molineaux, F.J. Casano, A.M. Rolando, E.P. Peterson, G. Limjuco, J. Chin, P.R. Griffin, J.R. Calaycay, G.J.-F. Ding, T.-T. Yamin, O.C. Palyha, S. Luell, D. Fletcher, D.K. Miller, A.D. Howard, N.A. Thornberry and M.J. Kostura, Proc. Natl. Acad. Sci. USA, 90, 1809 (1993)

For Laboratory use only! Not for Drug Use!