Caspase Inhibitors

Caspase inhibitors are individually designed by combination of caspase specific peptide sequences with functional groups. Due to the lower reactivity of the aldehyde (CHO) function, these type of caspase inhibitors act usually reversible whereas caspase inhibitors with chloromethylketone (CMK) and fluoromethylketone (FMK) react irreversible with the related enzyme. The specificity of the caspase inhibitor according to the target is determined by the specific enzyme recognition sequence. For example, the tripeptide Z-VAD-FMK is used as broad-range irreversible caspase inhibitor whereas the tetrapeptides Ac-YVAD-CHO and Ac-WEHD-CHO shows stronger, but reversible selectivity to Caspase-1. All caspase inhibitors offered from PeptaNova GmbH are synthetic products manufactured by our experienced partner Peptide Institute Inc. under highest quality standards.