Z-VAD-FMK

Z-VAD-FMK

Z-VAD-FMK

105,00 € excl. 19% VAT

SKU: 3188-v Category: Tags: ,

Z-VAD-FMK | Z-Val-Ala-Asp(OMe)-CH2F
synonym: Z-VAD(OMe)-FMK

3188-v 1 mg | 105.00 EUR

Carbobenzoxy- L-valyl- L-alanyl- β-Methyl- L-aspart-1-yl- Fluoromethane

(M.W. 467.49) C22H30N3O7F [187389-52-2]

Synthetic Product

Inhibitor for Caspases (specific pan Caspase inhibitor)

Z-VAD-FMK (Z-VAD(OMe)-FMK) is a cell permeable, non seletive inhibitor for caspase-1 and caspase-3 enzymes which shows no cytotoxic effects. The benzyloxycarbonyl protected tripeptide is commonly used as inhibitor for T cell apoptosis, staunosporin induced cell death and Fas-mediate apoptosis. Our Pan Caspase inhibitor is commonly used for inflammation and apoptose studies. The chemically manufactured methylester of Z-VAD-FMK is soluble in DMSO and other organic solvents, but insoluble in water. We will ship a product specific vial instruction sheet together with the peptide.

Z-VAD-FMK blocks caspases irreversible, but less selective, where as our inhibitor Ac-YVAD-CMK is specific for Caspase-1. We offer additionally the reversible Caspase-1 inhibitor Ac-YVAD-CHO. Our caspase inhibitors are manufactured in Japan by Peptide Institute Inc. and are usually available for prompt delivery ex stock Sandhausen.

Shipping | Storage | Stability
Our product Z-VAD-FMK will be shipped at room temperature. Information about product specific storage conditions will be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing by preparing aliquots.

References:

  1. E.A. Slee, H. Zhu, S.C. Chow, M. MacFarlane, D.W. Nicholson and G.M. Cohen, Biochem. J., 315, 21 (1996)
  2. H. Zhu, H.O. Fearnhead and G.M. Cohen, FEBS Lett., 3740, 303 (1995)
  3. D. Leung, G. Abbenante and D.P. Fairlie, J. Med. Chem., 43, 305 (2000)

Links to publications that use our caspase specific inhibitor Z-VAD-FMK | code 3188-v:

  1. Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner
  2. Inhibition of UV-C Light–Induced Apoptosis in Liver Cells by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin
  3. Determinants of acute and chronic renal allograft injury
  4. Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner

The related Caspase-1 substrate Ac-YVAD-AMC and Caspase-2 substrate Ac-VDVAD-AMC with the VAD Sequence is available from stock within short time .

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