Ac-YVAD-CMK | Ac-Tyr-Val-Ala-Asp-CH2Cl
Ac-YVAD-Chloromethylketone
3180-v 5 mg | 165.00 EUR
Acetyl- L-tyrosyl- L-valyl- L-alanyl- L-aspart-1-yl-Chloromethane
| (M.W. 541.00) | C24H33N4O8Cl | [178603-78-6] |
Synthetic Product
Irreversible Inhibitor for Caspase-1
Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CH2Cl) is used as an irreversible inhibitor for Caspase-1, instead of the pseudo acid (aldehyde) Ac-YVAD-CHO which inhibits caspase reversible. The caspase-1 inhibitor Ac-YVAD-CMK is of interest in reasearch of sepsis and endotoxic shock.
References:
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- M. Enari, H. Hug and S. Nagata, Nature, 375, 78 (1995)
- C.E. Milligan, D. Prevette, H. Yaginuma, S. Homma, C. Cardwell, L.C. Fritz, K.J. Tomaselli, R.W. Oppenheim and L.W. Schwartz, Neuron, 15, 385 (1995)
- E. Fujita, T. Mukasa, T. Tsukahara, K. Arahata, S. Omura and T. Momoi, Biochem. Biophys. Res. Commun, 224, 74 (1996)
