105,00  excl. 19% VAT

Ac-Asp-Glu-Val-Asp-AMC | Ac-DEVD-AMC

Ac-Asp-Glu-Val-Asp-MCA | Ac-DEVD-MCA

3171-v 5 mg | 105.00 EUR

Acetyl- L-aspartyl- L-glutamyl- L-valyl- L-aspartic acid α-(4-methyl- coumaryl- 7- amide)

(M.W. 675.65) C30H37N5O13 [169322-61-0]

Synthetic Product
A trace of impurity might be detectable by TLC when 100 µg is applied to the plate. The amount of contamination detectable by HPLC is less than 2 %.

Selective Substrate for Caspase-3/7/8 (apopain; Yama; CPP-32)

Ac-DEVD-AMC is a selective fluorogenic caspase substrate taken out of the sequence of the target enzyme Poly (ADP-ribose) polymerase. The fluorogenic tetrapeptide substrate Ac-DEVD-AMC is a useful tool for the identification and quantification of Caspase-3 activity in apoptotic cells. The fluorogenic AMC residue will be released by Caspase-3 activity and can be quantified in a spectrofluorometer. You can order the reference substance AMC (7-amino-4-methylcoumarin) Code: 3099-v in high quality for prompt delivery ex stock.

The related reversible inhibitor Ac-DEVD-CHO Code: 3172-v is available as well by PeptaNova.


  1. D.W. Nicholson et al, Nature, 376, 37 (1995)
  2. N.A. Thornberry et al, J. Biol. Chem, 272, 17907 (1997)

Links to publications that use our substrate Ac-Asp-Glu-Val-Asp-AMC | code 3171-v:

  1. Modulation of Mcl-1 transcription by serum deprivation sensitizes cancer cells to cisplatin
  2. When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157
  3. Human caspase-3 inhibition by Z-tLeu-Asp-H: tLeu(P2) counterbalances Asp(P4) and Glu(P3) specific inhibitor truncation
  4. Augmenter of liver regeneration attenuates inflammatory response in the postischemic mouse liver in vivo

For Laboratory use only!