D-GsMTx-4

4525-s 0.1 mg | 425.00 EUR

Gly -D-Cys – D-Leu – D-Glu – D-Phe – D-Trp – D-Trp – D-Lys – D-Cys – D-Asn – D-Pro – D-Asn – D-Asp – D-Asp – D-Lys – D-Cys – D-Cys – D-Arg – D-Pro – D-Lys – D-Leu – D-Lys – D-Cys – D-Ser – D-Lys – D-Leu – D-Phe – D-Lys – D-Leu – D-Cys – D-Asn – D-Phe – D-Ser – D-Phe – NH₂

Synthetic Product (disulfide bonds between Cys²-Cys¹⁷, Cys⁹-Cys²³ and Cys¹⁶-Cys³⁰)

The purity is guaranteed to be higher than 99% by HPLC

Inhibitor of Mechanosensitive Ion Channels (e.g. Piezo2)

References:

1. T.M. Suchyna, S.E. Tape, R.E.II Koeppe, O.S. Andersen, F. Sachs and P.A. Gottlieb, Nature, 430, 235 (2004) (Original)
2. C.L. Bowman, P.A. Gottlieb, T.M. Suchyna, Y.K. Murphy and F. Sachs, Toxicon, 49, 249 (2007) (Review)
3. C. Bae, F. Sachs and P.A. Gottlieb, Biochemistry, 50, 6295 (2011) (Piezo1 Channel Inhibitor)
4. R. Gnanasambandam, C. Ghatak, A. Yasmann, K. Nishizawa, F. Sachs, A.S. Ladokhin, S.I. Sukharev and T.M. Suchyna, Biophys J.,112, 31 (2017) (Mechanism Study of Inhibiting Mechanosensitive Ion Channels)
5. C. Alcaino, K. Knutson, P.A. Gottlieb, G. Farrugia and A. Beyder, Channels, 11, 245 (2017) (Piezo2 Channel Inhibitor)
6. M.M. Maneshi, L. Ziegler, F. Sachs, S.Z. Hua and P.A. Gottlieb, Sci. Rep., 8, 14267 (2018)