µ-Conotoxin GIIIB
(Marine Snail, Conus geographus)

4217-v 0.5 mg | 485.00 EUR

Synthetic Product (disulfide bonds between Cys³-Cys¹⁵, Cys⁴-Cys²⁰ and Cys¹⁰-Cys²¹)

Arg – Asp – Cys – Cys – Thr – Hyp – Hyp – Arg – Lys – Cys – Lys – Asp – Arg – Arg – Cys – Lys – Hyp – Met – Lys – Cys – Cys – Ala – NH₂

The purity is guaranteed to be higher than 99% by HPLC

Na⁺ Channel Blocker; Specific for Skeletal Muscle

The biological activity of this peptide is examined by the Division of Pharmacology, Peptide Institute, Inc.

Important information:
µ-Conotoxin GIIIB can be shipped to autorized endusers with own application labs only. We will need a dedicated end user declaration for this item and cannot ship conotoxin to trading companies!

References:

1. S. Sato, H. Nakamura, Y. Ohizumi, J. Kobajashi and Y. Hirata, FEBS Lett., 155, 277 (1983) (Original)
2. L.J. Cruz, W.R. Gray, B.M. Olivera, R.D. Zeikus, L. Knerr, D. Yoshikami and E. Mocyzydlowski, J. Biol. Chem., 260, 9280 (1985) (Naming
3. Y. Ohizumi, H. Nakamura, J. Kobajashi and W.A. Catteral, J. Biol. Che., 261, 6149 (1986) (Pharmacol)
4. S. Kubo, N. Chino, T.X. Watanabe, T. Kimura and S. Sakakibara, Pept. Res., 6, 66 (1993) (Chem. Synthesis and Pharmacol.)

Links to publications that use our peptide µ-Conotoxin GIIIB | code 4217-v:

1. Ursachen der Insulin- und Katecholamin-induzierten Membranhyperpolarisation am Skelettmuskel
   
2. Low dystrophin levels are insufficient to normalize the neuromuscular synaptic abnormalities of mdx mice