ω-Agatoxin IVA
ω-Aga-IVA | Omega-Agatoxin IVA | omega-Aga-IVA (Funnel Web Spider, Agelenopsis aperta)

4256-s 0.1 mg | 265.00 EUR

Synthetic Product, not from animal origin (Disulfide bonds between Cys⁴-Cys²⁰, Cys¹²-Cys²⁵, Cys¹⁹-Cys³⁶ and Cys²⁷-Cys³⁴)

Lys – Lys – Lys – Cys – Ile – Ala – Lys – Asp – Tyr – Gly – Arg – Cys – Lys – Trp – Gly – Gly – Thr – Pro – Cys – Cys – Arg – Gly – Arg – Gly – Cys – Ile – Cys – Ser – Ile – Met – Gly – Thr – Asn – Cys – Glu – Cys – Lys – Pro – Arg – Leu – Ile – Met – Glu – Gly – Leu – Gly – Leu – Ala

The purity is guaranteed to be higher than 99% by HPLC

The neuropeptide toxin Omega-Agatoxin IVA is a strong P-type Ca²⁺ Channel selective blocker. Omega-Aga-IVA is altering the voltage-dependent gating, so that very large depolarizations are needed for channel opening. It blocks also the Q-type Ca²⁺-channels. These specific Ca²⁺-channels are essential for the release of neurotransmitters in nerve terminals of mammalians.

References:

1. I.M. Mintz, V.J. Venema, K.M. Swiderek, T.D. Lee, B.P. Bean, and M.E. Adams, Nature, 355, 827 (1992)(Original)
2. T.J. Turner, M.E. Adams, and K. Dunlap, Science, 258, 310 (1992) (Pharmacol)
3. H. Nishio, K.Y. Kumagaye, S. Kubo, Y.-N. Chen, A. Momiyama, T. Takahashi, T. Kimura, and S. Sakakibara, Biochem. Biophys. Res. Commun, 196, 1447 (1993) (Chemical synthesis of omega-Agatoxin IVA and Biological activity)

Links to publications that use our peptide Omega-Agatoxin IVA (ω-Agatoxin IVA) | code 4256-s:

1. Regulation by L channels of Ca²⁺-evoked secretory responses in ouabain-treated chromaffin cells
2. Altered synaptic transmission at olfactory and vomeronasal nerve terminals in mice lacking N-type calcium channel Cav2.
   

Omega-Agatoxin IVA is distributed in the USA through Peptide Institute, Inc. Omega-Agatoxin IVA is not available in the USA via PeptaNova.

For Laboratory use only! Not for Drug Use!