ω-Agatoxin TK
omega-Agatoxin-TK | ω-Aga-TK (Funnel Web Spider, Agelenopsis aperta)

4294-s 0.1 mg | 295.00 EUR

Synthetic Product (Disulfide bonds between Cys⁴-Cys²⁰, Cys¹²-Cys²⁵, Cys¹⁹-Cys³⁶ and Cys²⁷-Cys³⁴)

Glu – Asp – Asn – Cys – Ile – Ala – Glu – Asp – Tyr – Gly – Lys – Cys – Thr – Trp – Gly – Gly – Thr – Lys – Cys – Cys – Arg – Gly – Arg – Pro – Cys – Arg – Cys – Ser – Met – Ile – Gly – Thr – Asn – Cys – Glu – Cys – Thr – Pro – Arg – Leu – Ile – Met – Glu – Gly – Leu – D-Ser – Phe – Ala

The purity is guaranteed to be higher than 99% by HPLC

omega-Agatoxin TK is a selective channel blocker for the P-type Ca²⁺ Channel

The neuropeptide toxin omega-Agatoxin TK was originally isolated in the venom of the funnel web spider Agelenopsis aperta. Omega-Aga-TK from Peptide Institute is a syntheic peptide, manufactured by chemical peptide synthesis and is not isolated from animal sources.

Omega-Agatoxin IVB is often used as synonym for Omega-Agatoxin TK.

References:

1. M. Kuweda, T. Teramoto, K.J. Kumagaye, K. Nakajima, T. Watanabe, T. Kawai, Y. Kawakami, T. Niidome, K. Sawada, Y. Nishizawa and K. Katayama, Mol. Pharmacol, 46, 587 (1994) (Original)
2. Y. Shikata, T. Watanabe, T. Teramoto, A. Inoue, Y. Kawakami, Y. Nishizawa, K. Katayama and M. Kuweda, J. Biol. Chem., 270, 16719 (1995) (L-Ser to D-Ser Isomerase)
3. T. Kozaki, M. Kuweda, M. Narukawa, Y. Nagai and N. Asakawa, Peptide Chemistry 1995, 245 (1996) (Pharmacol.)
4. T. Teramoto, T. Nidome, M. Kimura, M. Ohgoh, Y. Nishizawa, K. Katayama, T. Mayumi and K. Saweda, Brain. Res., 7456, 225 (1997) (Pharmacology of omega-Agatoxin TK.)

For Laboratory use only! Not for Drug Use!