Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde
Z-Ile-Glu(OtBu)-Ala-Leu-CHO
Z-Ile-Glu(OBut)-Ala-Leu-H (aldehyde) | PSI
3169-v 5 mg | 85.00 EUR
Benzyloxycarbonyl- L-isoleucyl- γ-t-butyl- L-glutamyl- L-alanyl- L-leucinal
| (M.W. 618.77) | C32H50N4O8 | [158442-41-2] |
Synthetic Product
Inhibitor for Proteasome
The protected tetrapeptide Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde inhibts selectively chymotrypsin-like activities in MPC proteasome. Additionally, Z-Ile-Glu(OBut)-Ala-Leu-H (aldehyd) acts as anti-neoplytic agent and induces apoptosis in different leucaemia cell lines. Furthermore PSI is an inhibitor for the deubiquitinating Enzyme.
For Laboratory use only! Not for Drug Use! References:
- M.E. Figueiredo-Pereira, K.A. Berg and S. Wilk, J. Neurochem., 63, 1578 (1994)
- E.B.-M. Traenckner, S. Wilk and P.A. Baeuerle, EMBO J., 13, 5433 (1994)
