Z-Ile-Glu(OBut)-Ala-Leu-H (aldehyde) | PSI

Z-Ile-Glu(OBut)-Ala-Leu-H (aldehyde) | PSI

85,00  excl. 19% VAT

SKU: 3169-v Category: Tag:

Z-Ile-Glu(OBut)-Ala-Leu-H (aldehyde) | PSI

3169-v 5 mg | 85.00 EUR

Benzyloxycarbonyl- L-isoleucyl- γ-t-butyl- L-glutamyl- L-alanyl- L-leucinal

(M.W. 618.77) C32H50N4O8 [158442-41-2]

Synthetic Product

Inhibitor for Proteasome

The protected tetrapeptide Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde inhibts selectively chymotrypsin-like activities in MPC proteasome. Additionally, Z-Ile-Glu(OBut)-Ala-Leu-H (aldehyd) acts as anti-neoplytic agent and induces apoptosis in different leucaemia cell lines. Furthermore PSI is an inhibitor for the deubiquitinating Enzyme.

For Laboratory use only! Not for Drug Use! References:

  1. M.E. Figueiredo-Pereira, K.A. Berg and S. Wilk, J. Neurochem., 63, 1578 (1994)
  2. E.B.-M. Traenckner, S. Wilk and P.A. Baeuerle, EMBO J., 13, 5433 (1994)