Purotoxin-1
(Wolf Spider, Geolycosa sp.)

4457-s 0.1 mg | 160.00 EUR

Gly – Tyr – Cys – Ala – Glu – Lys – Gly – Ile – Arg – Cys – Asp – Asp – Ile – His – Cys – Cys – Thr – Gly – Leu – Lys – Cys – Lys – Cys – Asn – Ala – Ser – Gly – Tyr – Asn – Cys – Val – Cys – Arg – Lys – Lys

Synthetic Product (reported disulfide bonds between Cys³ – Cys¹⁶, Cys¹⁰ – Cys²¹, Cys³ – Cys¹⁶ and Cys¹³ – Cys³⁰ )

The purity is guaranteed to be higher than 99% by HPLC

Inhibitor of P2X3 Purinoreceptors

Purotoxin-1, is composed of 35 amino acid residues with 4 disulfide bonds and was originally isolated from the venom of the Wolf Spider.
P2X3 purinoreceptors are one component participating in pain signaling. The peptide reduced capsaicin-induced nociception in rat at low doses. Purotoxin-1 may helpful for the development of novel antinociceptive drugs.

Shipping | Storage | Stability
Our product Purotoxin-1 will be shipped at room temperature. Information about product specific storage conditions will be found on the vial.

References:

1. E.V. Grishin, G.A. Savchenko, A.A. Vassilevski, Y.V. Korolkova, Y.A. Boychuk, V.Y. Viatchenko-Karpinski, K.D. Nadezhdin, A.S. Arseniev, K.A. Pluzhnikov, V.B. Kulyk, N.V. Voitenko and O.O. Krishtal, Ann. Neurol., 67, 680 (2010) (Original; Structure and Pharmacol.)