Imperatoxin A
IpTXa
(Scorpion, Pandinus imperator)

4343-s 0.1 mg | 225.00 EUR

Gly – Asp – Cys – Leu – Pro – His – Leu – Lys – Arg – Cys – Lys – Ala – Asp – Asn – Asp – Cys – Cys – Gly – Lys – Lys – Cys – Lys – Arg – Arg – Gly – Thr – Asn – Ala – Glu – Lys – Arg – Cys – Arg

Synthetic Product (disulfide bonds between Cys³-Cys¹⁷, Cys¹⁰-Cys²¹ and Cys¹⁶-Cys³²)

The purity of Imperatoxin A is guaranteed to be higher than 99% by HPLC

Activator of Ca²⁺ Release Channels / Ryanodine Receptors

Imperatoxin A is a 33 residue peptide toxin originally isolated from the venom of Scorpion, Pandinus imperator. IpTXa is a potent modifier for the RyR1 and RyR3 channels with high affinity. Imperatoxin A enhances calcium release and is a strong agonist of ryanodine receptors.

Shipping | Storage | Stability
Our product Imperatoxin A (IpTXa) will be shipped at room temperature. Information about product specific storage conditions will be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing by preparing aliquots.

References:

1. H.H. Valdivia, M.S. Kirby, W.J. Lederer and R.Coronado, Proc. Natl. Acad. Sci. USA, 89, 12185 (1992) (Pharmacol.)
2. R. El-Hayek, A.J. Lokuta, C. Arévalo and H.H. Valdivia, J. Biol. Chem., 270, 28692 (1995) (Pharmacol)
3. F.Z. Zamudio, G.B. Gurrola, C. Arévalo, R. Sreekumar, J.W. Walker, H.H. Valdivia and L.D. Possani, FEBS Lett., 405, 385 (1997) (Original; Structure)
4. K. Takeuchi, J.I. Kim, H. Takahashi, K. Sato and I. Shimada, Peptide Science 1999, 307, (2000) (S-S Bond)

For Laboratory use only! Not for Drug Use!