Huwentoxin-IV
HWTX-IV
(Chinese Bird Spider, Ornithoctonus huwena)

4455-s 0.1 mg | 195.00 EUR

Glu – Cys – Leu – Glu – Ile – Phe – Lys – Ala – Cys – Asn – Pro – Ser – Asn – Asp – Gln – Cys – Cys – Lys – Ser – Ser – Lys – Leu – Val – Cys – Ser – Arg – Lys – Thr – Arg – Trp – Cys – Lys – Tyr – Gln – Ile – NH₂

Synthetic Product (Disulfide bonds between Cys² – Cys¹⁷, Cys⁹ – Cys²⁴, and Cys¹⁶ – Cys³¹)

The purity of our product Huwentoxin-IV is guaranteed to be higher than 99% by HPLC

Neuronal Tetrodotoxin-Sensitive Na+-Channel Blocker

Huwentoxin-IV, HWTX-IV) was originally isolated from the Chinese Bird Spider venom. The 35 residue peptide build 3 disulfid bridges and is a potent inhibitor of neuronal voltage gated sodium channels.

References:

1. K. Peng, Q. Shu, Z. Liu and S. Liang, J. Biol. Chem., 277, 47564 (2002) (Original)
2. J. Diao, Y. Lin, J. Tang and S. Liang, Toxicon, 42, 715 (2003) (cDNA Seq.)
3. Y. Xiao, J.-P. Bingham, W. Zhu, E. Moczydlowski, S. Liang and T.R. Cummins, J. Biol. Chem., 283, 27300 (2008) (Pharmacology)
4. Y. Xiao, X. Luo, F. Kuang, M. Deng, M. Wang, X. Zeng and S. Liang, Toxicon, 51, 230 (Pharmacol.)