165,00  excl. 19% VAT


4321-v 5 mg | 165.00 EUR


(M.W. 342.44) C17H30N2O5 [88321-09-9]

Synthetic Product

Inhibitor for Thiol Protease (Cathepsin B/H/L, Calpain)

E-64-d is the membrane permeable analog of the inhibitor E-64-c. By the chemical point of view, E-64-d is the ethylester of the Thiol Protease inhibitor E-64-c, which will released from E-64d after hydrolysis by intracellular esterases. It is reported that E-64-d inhibits degradation of plasma membrane proteins in endosomes and prevents both calpain upregulation and apoptosis. The inhibitor E-64-d offered from PeptaNova is chemically manufactued and not from biological origin.

The standard inhibitor for cystein proteases E-64 is also available for prompt delivery ex stock.


  1. M. Tamai, K. Matsumoto, S. Omura, I. Koyama, Y. Ozawa and K. Hanada, J. Pharmacobio-Dyn., 9, 672 (1986) (Original)
  2. M. Tamai, C. Yokoo, M. Murata, K. Oguma, K. Sota, E. Sato and Y. Kanaoka, Chem. Pharm. Bull., 35, 1098 (1987) (Chem. Structure & Biochemistry of E-64-d)

For Laboratory use only! Not for Drug Use!