155,00  excl. 19% VAT

L-trans-Epoxysuccinyl-Ile-Pro-OH propylamide

4322-v 5 mg | 155.00 EUR

(L- 3- trans- (Propylcarbamoyl)oxirane- 2- Carbonyl) L-isoleucyl- L-proline

(M.W. 383.44) C18H29N3O6 [134448-10-5]

Synthetic Product

Inhibitor for Cathepsin B

CA-074 (Cathepsin B Inhibitor III) is a selective irreversible inhibitor of cathepsin B with lower membrane permeability as the related methyl ester CA-074 Me. The more specific inhibitor CA-074 enables the inhibition of endogenous cathepsin B, while intracellular cathepsin L remains unaffected. It should be used instead of CA-074 Me for the specific inactivation of cathepsin B in living cells.

Download: PDF Data Sheet


  1. M. Murata, S. Miyashita, C. Yokoo, M. Tamai, K. Hanada, K. Hatayama, T. Towatari, T. Nikawa and N. Katunuma, FEBS Lett., 280, 307 (1991) (Original; Pharmacol.)
  2. T. Towatari, T. Nikawa, M. Murata, C. Yokoo, M. Tamai, K. Hanada and N. Katunuma, FEBS Lett., 280, 311 (1991) (Original; Pharmacology of CA-074)
  3. T. Inubushi, H. Kakegawa, Y. Kishino and N. Katsunuma, J. Biochem., 116, 282 (1994) (Biochemisty of CA-074.)

Links to publications that use our Cathepsin B Inhibitor III) CA-074 | code 4322-v:

  1. Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21

The peptide inhibitor CA-074 is distributed through Peptide Institute, Inc. under the license of Taisho Pharmaceutical Co., Ltd.

For Laboratory use only! Not for Drug Use!