Dendrotoxin I
(Black Mamba, Dendroaspis polylepis polylepis)

4330-s 0.1 mg | 195.00 EUR

Pyr – Pro – Leu – Arg – Lys – Leu – Cys – Ile – Leu – His – Arg – Asp – Pro – Gly – Arg – Cys – Tyr – Gln – Lys – Ile – Pro – Ala – Phe – Tyr – Tyr – Asn – Gln – Lys – Lys – Lys – Gln – Cys – Glu – Gly – Phe – Thr – Trp – Ser – Gly – Cys – Gly – Gly – Asn – Ser – Asn – Arg – Phe – Lys – Thr – Ile – Glu – Glu – Cys – Arg – Arg – Thr – Cys – Ile – Arg – Lys

Synthetic Product (disulfide bonds between Cys⁷-Cys⁵⁷, Cys¹⁶-Cys⁴⁰ and Cys³²-Cys⁵³)

The purity is guaranteed to be higher than 99% by HPLC

Dendrotoxin I is a potent voltage Depent K⁺ Channel Blocker. This synthetic peptide toxin is originally isolated from the african black mamba snake venom. Dendrotoxin I shows a significant structure-activity relationship to Calcicludine but acting on different targets. Dendrotoxin I belongs together with MCD Peptide to the group of fast activating and slow inactivation K⁺ ion channel blockers.

References:

1. D.J. Strydom, Nature New Biol., 243, 88 (1973) (Original description of Dendrotoxin I)
2. J.-N. Bidard, C. Mourre, and M. Lazdunski, Biochem. Biophys. Res. Commun, 143, 383 (1989) (Pharmacol.)
3. A.L. Harvey, D.L. Marshall, F.A. De-Allie and P.N. Strong, Biochem. Biophys. Res. Commun, 163, 394 (1989) (Pharmacology of Dendrotoxin I)
4. H. Nisho, T. Inui, Y. Nishiuchi, C.L.C. De Medeiros, E.G. Rowan, A.L. Harvey, E. Katoh, T. Yamazaki, T. Kimura and S. Sakakibara, J. Pept. Res., 51, 355 (1998) (Chem. Synthesis of Dendrotoxin I and Correction of Sequence; Asp¹²)

For Laboratory use only! Not for Drug Use!