Alpha-Defensin-3 (Human)

Alpha-Defensin-3 (Human)

140,00  excl. 19% VAT

Alpha-Defensin-3 (Human)
α-Defensin-3 | HNP-3 (Human Neutrophil Peptide-3)

4416-s 0.1 mg | 140.00 EUR

Synthetic Product (disulfide bonds between Cys2-Cys30, Cys4-Cys19 and Cys9-Cys29)

Asp – Cys – Tyr – Cys – Arg – Ile – Pro – Ala – Cys – Ile – Ala – Gly – Glu – Arg – Arg – Tyr – Gly – Thr – Cys – Ile – Tyr – Gln – Gly – Arg – Leu – Trp – Ala – Phe – Cys – Cys

(M.W. 3486.0) C151H222N44O40S6

The purity of alpha-Defensin-3 is guaranteed to be higher than 99% by HPLC

Antimicrobial Peptide

Defensin is one of the potential protecting factors against microbial infection. In human, α-Defensins (Alpha-Defensin) and β-Defensins (Beta-Defensin) are known, which are characterized by their distinct arrangement of three disulfide bridges.
To date, six human α-Defensins are classified into two sub-groups: one group is composed of human neutrophil peptides (HNP), HNP-1 to HNP-4, and the other group is human defensin (HD), HD-5 and HD-6. In addition to human alpha-defensin-1 (HNP-1), we now introduce two new members of the Defensin family, alpha-Defensin-3 (HNP-3) and human alpha-defensin-5 (HNP-5).
HNP-1 to HNP-3 are the major components in azophilic granules of human neutrophils. The primary structures of HNP-1 to HNP-3 differ by only one amino acid residue at position 1; HNP-2 corresponds to position 2 through 30 of HNP-1 while HNP-3 is Asp1-HNP-1. Recent interesting publications using HNP include i) HNP-1 to HNP-3 are secreted upon stimulation of CD8 cells from non-progressors of HIV-1 infection, thus, these three peptides may show anti-HIV-1 activity, and ii) HNP-1 to HNP-3 are overexpressed in squamous cell carcinomas of the human tongue, representing a possible role in innate host defense against tumor invasion. It has been reported that expression of HNP-1 to HNP-3 is not upregulated by lipopolysaccharide, while they locate in intestinal epithelian cells in cases of inflammatory bowel disease.


  1. T. Ganz, M.E. Selstedt, D. Szklarek, S.S.L. Harwig, K. Daher, D.F. Bainton and R.I. Lehrer, J. Clin. Invest., 76, 1427 (1985) (Original; Isolation of HNP 1-3)
  2. M.E. Selstedt, S.S.L. Harwig, T. Ganz, J.W. Schilling and R.I. Lehrer, J. Clin. Invest., 76, 1436 (1985) (Original; Structure of HNP 1-3)
  3. F.T. Lundy, D.F. Orr, J.R. Gallagher, P. Maxwell, C. Shaw, S.S. Napier, C.G. Cowan, P.J. Lamey and J.J. Marley, Oral. Oncol., 40, 139 (2004) (Pharmacol.; Role in Tumor Invasion)