Alpha-Defensin-4 (Human)
α-Defensin-4 | HNP-4 (Human Neutrophil Peptide-4)

4431-s 0.1 mg | 235.00 EUR

Synthetic Product (disulfide bonds between Cys²-Cys³⁰, Cys⁴-Cys¹⁹ and Cys⁹-Cys²⁹)

Val – Cys – Ser – Cys – Arg – Leu – Val – Phe – Cys – Arg – Arg – Thr – Glu – Leu – Arg – Val – Gly – Asn – Cys – Leu – Ile – Gly – Gly – Val – Ser – Phe – Thr – Tyr – Cys – Cys – Thr – Arg – Val

The purity of alpha-Defensin-4 is guaranteed to be higher than 99% by HPLC

HNP-4 (Human) | Alpha-Defensin-4 (Human) is described as an inhibitor of the ACTH action in rat adrenal cell suspension and shows distinct antimicrobial activity and antiviral activity against X4 and R5 HIV strains. Inhibition of Bacillus anthracis lethal factor is reported.

References:

1. A. Singh, A. Bateman, Q. Zhu, S. Shimasaki, F. Esch and S. Solomon, Biochem. Biophys. Res. Commun., 155, 524 (1988) (Original primary structure and Anti ACTH Activity)
2. C.G. Wilde, J.E. Griffith, M.N. Marra, J.L. Snable, and R.W. Scott,J. Biol. Chem., 264, 11200 (1989) (Structure of HNP-4 and antimicrobial activity)
3. Z. Wu, B. Ericksen, K. Tucker, J. Lubkowski, and W. Lu,J. Pept. Res., 64, 118 (2004) (Pharmacol. and antimicrobial activity)

For Laboratory use only!