Psalmotoxin 1 | PcTX1
(South American Tarantula, Psalmopoeus cambridgei)
4435-s 0.1 mg | 150.00 EUR
Glu- Asp- Cys- Ile- Pro- Lys- Trp- Lys- Gly- Cys- Val- Asn- Arg- His- Gly- Asp- Cys- Cys- Glu- Gly- Leu- Glu- Cys- Trp- Lys- Arg- Arg- Arg- Ser- Phe- Glu- Val- Cys- Val- Pro- Lys- Thr- Pro- Lys- Thr
| (M.W. 4689.4) | C200H312N62O57S6 |
Synthetic Product Trifluoracetate Form (disulfide bonds between Cys3– Cys18, Cys10– Cys23 and Cys17– Cys33 )
The purity is guaranteed to be higher than 99% by HPLC
Selective Blocker for Acid-Sensitive Ion Channel, ASIC1a
Psalmotoxin 1 (PcTX1), a peptide toxin composed of 40 amino acid residues was originally isolated from the venom of the West Indies tarantula Psalmopoeus cambridgei. It inhibits cation currents mediated by acid-sensing ion channels (ASIC). Psalmotoxin 1 shows high analgesic properties in mice and rat models.
Shipping | Storage | Stability
Our product Psalmotoxin 1 (PcTX1) will be shipped at room temperature. Information about product specific storage conditions will be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing by preparing aliquots.
References:
- P. Escoubas, J.R. De Weille, A. Lecoq, S. Diochot, R. Waldmann, G. Champigny, D. Moinier, A. Ménez and M. Lazdunski, J. Biol. Chem., 275, 25116 (2000) (Original; Primary Structure & ASIC Blocking S)
- J.K. Bubien, H.-L. Ji, G.Y. Gillespie, C.M. Fuller, J.M. Markert, T.B. Mapstone and D.J. Benos, Am. J. Physiol., 287, C1282 (2004) (Pharmacol.)
- X. Chen, H. Kalbacher and S. Gründer, J. Gen. Physiol., 126, 71 (2005) (Pharmacol.)
- X. Chen, H. Kalbacher and S. Gründer, J. Gen. Physio., 127, 267 (2006) (Pharmacol.)
Links to publications that use our peptide Psalmotoxin (PcTX1) | code 4435-s:
