ProTX-II (Protoxin-II)
(Tarantula, Thrixopelma pruriens)

4450-s 0.1 mg | 150.00 EUR

Tyr- Cys- Gln- Lys- Trp- Met- Trp- Thr- Cys- Asp- Ser- Glu- Arg- Lys- Cys- Cys- Glu- Gly- Met- Val- Cys- Arg- Leu- Trp- Cys- Lys- Lys- Lys- Leu- Trp

Synthetic Product (disulfide bonds between Cys²– Cys¹⁶, Cys⁹– Cys²¹ and Cys¹⁵– Cys²⁵ ) and not from animal origin

The purity is guaranteed to be higher than 99% by HPLC

Na⁺ Channel (Especially Nav1.7) / Ca²⁺ Channel Blocker (Gating Modifier)

ProTx-II was originally isolated from the venom of the tarantula Thrixopelma pruriens. Potent channel blocker with high selectivity for Nav1.7 channel.
ProTx-II is a potent inhibitor for tetrodotoxin-sensitive and tetrodotoxin-resistant voltage-gated sodium channels. The Nav1 type channels exists in different sub types and ProTx-II shows a special affinity to the Nav1.7 channel which is responsible for pain processing.

References:

1. R.E. Middleton, V.A. Warren, R.L. Kraus, J.C. Hwang, C.J. Liu, G. Dai, R.M. Brochu, M.G. Kohler, Y.-D. Gao, V.M. Garsky, M.J. Bogusky, J.T. Mehl, C.J. Cohen and M.M. Smith, Biochemistry, 41, 14734 (2002) (Original)
2. J.J. Smith, T.R. Cummins, S. Alphy and K.M. Blumenthal, J. Biol. Chem., 282, 12687 (2007) (Pharmacol.; Novel Toxin Binding Site Coupled to NaV Activation)
3. W.A. Schmalhofer, J. Calhoun, R. Burrows, T. Bailey, M.G. Kohler, A.B. Weinglass, G.J. Kaczorowski, M.L. Garcia, M. Koltzenburg and B.T. Priest, Mol. Pharmacol., 74, 1476 (2008) (Pharmacol.; Inhibition of Nav1.7 Channel)
4. B.T. Priest, K.M. Blumenthal, J.J. Smith, V.A. Warren, and M.M. Smith, Toxicon, 49, 194 (2007) (Review)

Links to publications that use our peptide Protoxin II (ProTX-II) | code 4450-s:

1. Characterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp Screening