Calciseptine
(Black Mamba, Dendroaspis polylepis polylepis)

4255-s 0.1 mg | 255.00 EUR

Arg – Ile – Cys – Tyr – Ile – His – Lys – Ala – Ser – Leu – Pro – Arg – Ala – Thr – Lys – Thr – Cys – Val – Glu – Asn – Thr – Cys – Tyr – Lys – Met – Phe – Ile – Arg – Thr – Gln – Arg – Glu – Tyr – Ile – Ser – Glu – Arg – Gly – Cys – Gly – Cys – Pro – Thr – Ala – Met – Trp – Pro – Tyr – Gln – Thr – Glu – Cys – Cys – Lys – Gly -Asp – Arg – Cys – Asn – Lys

Synthetic Product (disulfide bonds between Cys³-Cys²², Cys¹⁷-Cys³⁹Cys⁴¹-Cys⁵² and Cys⁴³-Cys⁵⁸ )

The purity is guaranteed to be higher than 99% by HPLC

L-type Ca²⁺ Channel Blocker

The biological activity of Calciseptine is examined by the Division of Pharmacology, Peptide Institute, Inc.

Calciseptine is a neuropeptide toxin originally isolated from the venom of the african snake Black Mamba (Dendroaspis polylepis polylepis). It is an unusually great peptide toxin with a molweight greater than 7k. Calciseptine blocks specifically L-type Ca²⁺ channels and shows no activity against N-type and T-type Ca²⁺ channels. On the other hand, Calciseptine blocks spontaneous K⁺-induced contraction of cardiac and smooth muscle cells.
Calciseptine purchased from PeptaNova is a synthetic peptide manufactured by Peptide Institute, Inc.

References:

1. J.R. DeWeille, H. Schwetz, P. Maes, A. Tartar and M. Lazdunski, Proc. Natl. Acad. Sci. USA, 88, 2437 (1991) (Original Description of Calciseptine)
2. H. Kuroda, Y.N. Chen, T.X. Watanabe, T. Kimura and S. Sakakibara, Pept. Res., 5, 265 (1992) (Chem. Synthesis of Calciseptine)
3. T.X. Watanabe, Y. Itahara, H. Kuroda, Y.N. Chen, T. Kimura and S. Sakakibara, Jpn. J. Pharmacol., 68, 305 (1995) (Pharmacology of Calciseptine)
4. N. Teramoto, R. Ogata, K. Okabe, A. Kameyama, M. Kamayama, T.X. Watanabe, H. Kuriyama and K. Kitamura, Pflügers Arch., 432, 462 (1996) (Pharmacol)