155,00  excl. 19% VAT

SKU: 4368-v Category:


4368-v 0.2 mg | 155.00 EUR

N-Acetyl- L-Cysteine- S- [(2R,3S,4R)- 3-Hydroxy- 2- [(1S)- 1- Hydroxy- 2- Methylpropyl]- 4- Methyl- 5- Oxo- 2-Pyrrolidinecarbonyl]

(M.W. 376.43) C15H24N2O7S [133343-34-7]

Microbial Product

Inhibitor for Proteasome

Lactacystin, a freeze dried microbial product is soluble in Water, DMF, DMSO, Acetonitril or Alcohol. This inhibitor can be easily prepared as a 10 mM stock solution in DMSO and stored at – 80 °C.
Cardiological experiments indicated positive effects of Lactacystine on migration and growth of vascular smooth muscle cells. The proteasome inhibitors
Z-Leu-Leu-Leu-H [MG-132] and Lactacystine where described as potent inhibitors for the degradation of 1–512 HDC. It is reported that Lactacystin may induce Apoptosis in monoblastoma cells.


  1. S. Omura, T. Fujimoto, K. Otoguro, K. Matsuzaki, R. Moriguchi, H. Tanaka and Y. Sasaki, J. Antibiotics, 44, 113 (1991) (Original)
  2. G. Fenteany, R.F. Standaert, W.S. Lane, S. Choi, E.J. Corey and S.L. Schreiber, Science, 268, 726 (1995) (Biochem.; Proteasome Inhibition by Lactacystin)
  3. S. Imajoh-Ohmi, T. Kawaguchi, S. Sugiyama, K. Tanaka, S. Omura and H. Kikuchi, Biochem. Biophys. Res. Commun, 217, 1070 (1995) (Biochem.; Apoptotic Effect of Lactacystin)
  4. D. Leung, G. Abbenante and D.P. Fairlie, J. Med. Chem., 43, 305 (2000)