98,00  excl. 19% VAT

SKU: 3219-v Category:

(3,5-Difluorophenylacetyl)-Ala-Phg-OBut | (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu

3219-v 5 mg | 98.00 EUR

(3,5- Difluorophenylacetyl)- L-alanyl- L-2-phenylglycine t-butyl ester

(M.W. 432.46) C23H26N2O4F2

Synthetic Product

Inhibitor for γ-Secretase

The abbreviation DAPT stands for Difluorophenylacetyl)-alanyl-phenylglycine-t-butyl-ester. DAPT is a commonly used cell permeable inhibitor for enzymes of the secretase family and may be a helpful tool in the study of β-amyloid formation in Alzheimer´s disease. Notch signaling in hybrid human-mouse fetal thymus organ culture was inhibited by treatment with DAPT. This γ-Secretase inhibitor may be useful in research of autoimmune diseases.
The protected dipeptide ester offered in vials of 5 mg is of synthetic origin. DAPT is soluble in DMSO, Ethanol or other organic solvents.


  1. H.F. Dovey et al, J. Neurochem., 76, 173 (2001). (DAPT | Functional γ-Secretase Inhibitor in brain)
  2. A.Y. Kornilova, C. Das and M.S. Wolfe, J. Biol. Chem., 278, 16470 (2003). (Comparison of in Cells and Cell-Free Activity)
  3. Sousuke Yagishita, Maho Morishima-Kawashima, Yu Tanimura, Shoichi Ishiura and Yasuo Ihara, Biochemistry, 2006, 45 (12), pp 3952–3960 (DAPT-Induced Intracellular Accumulations of Longer Amyloid β-Proteins: Further Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase)