Orexin B (Human)

Orexin B (Human)

85,00  excl. 19% VAT

SKU: 4348-s Category:

Orexin B (Human)

4348-s 0.1 mg | 85.00 EUR

Arg – Ser – Gly – Pro – Pro – Gly – Leu – Gln – Gly – Arg – Leu – Gln – Arg – Leu – Leu – Gln – Ala – Ser – Gly – Asn – His – Ala – Ala – Gly – Ile – Leu – Thr – Met – NH2

(M.W. 2899.3) C123H212N44O35S [205640-91-1]

Synthetic Product

The purity is guaranteed to be higher than 99% by HPLC

Appetite-Boosting Peptide

Orexin-B is a linear 28-residue peptide. The mutual sequence similarity to Orexin-A is high, especially in their C-terminal regions. Human, rat and mouse peptide sequences have been determined and the primary structure of orexin-A is completely conserved among these species including bovine. Orexin B stimulates food intake in a dose-dependent manner (3/30 nmol) for a few hours with slight duration difference. In addition, hypothalamic orexin mRNA is found to be up-regulated in fasting. Orexin-B and A are coded tandemly in the same mRNA flanked by the double basic amino acid residues.

The same mRNA was isolated by another group from rat hypothalamic mRNA clone; the putative reading frames corresponding to orexin-A and B are named hypocretin based on the sequence similarity to secretin. [Proc. Natl. Acad. Sci., 95, 322 (1998)]

Shipping | Storage | Stability
Our product Orexin B will be shipped at room temperature. Information about product specific storage conditions can be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing by preparing aliquots.


  1. T. Sakurai, A. Amemiya, M. Ishii, I. Matsuzaki, R.M. Chemelli, H. Tanaka, S.C. Williams, J.A. Richardson, G.P. Kozlowski, S. Wilson, J.R.S. Arch, R.E. Buckingham, A.C. Haynes, S.A. Carr, R.S. Annan, D.E. McNulty, W.-S. Liu, J.A. Terrett, N.A. Elshourbagy, D.J. Bergsma and M. Yanagisawa, Cell, 92, 573 (1998) (Original)
  2. L. de Lecea, T.S. Kilduff, C. Peyron, X.-B. Gao, P.E. Foye, P.E. Danielson, C. Fukuhara, E.L.F. Battenberg, V.T. Gautvik, F.S. Bartlett II, W.N. Frankel, A.N. van den Pol, F.E. Bloom, K.M. Gautvik and J.G. Sutcliffe, Proc. Natl. Acad. Sci. USA, 95, 322 (1998) (cDNA; SAme Sequence [Hypocretin])