Orexin A (Human)

Orexin A (Human)

165,00  excl. 19% VAT

SKU: 4346-s Category:

Orexin A (Human)
(Rat, Mouse, Bovine)

4346-s 0.1 mg | 165.00 EUR

Pyr – Pro – Leu – Pro – Asp – Cys – Cys – Arg – Gln – Lys – Thr – Cys – Ser – Cys – Arg – Leu – Tyr – Glu – Leu – Leu – His – Gly – Ala – Gly – Asn – His – Ala – Ala – Gly – Ile – Leu – Thr – Leu – NH2

(M.W. 3561.1) C152H243N47O44S4 [205640-90-0]

Synthetic Product (Disulfide bonds between Cys6– Cys12 and Cys7– Cys14)

The purity is guaranteed to be higher than 99% by HPLC

Appetite-Boosting Peptide

Orexin A is a 33-residue peptide with two intramolecular disulfide linkages, while Orexin B is a linear 28-residue peptide. The mutual sequence similarity is high, especially in their C-terminal regions. Human, rat and mouse peptide sequences have been determined and the primary structure of orexin-A is completely conserved among these species including bovine. When orexin-A and B are administered into the lateral hypothalamus (the brain’s “feeding center”), food intake was stimulated in a dose-dependent manner (3/30 nmol) for a few hours with slight duration difference. In addition, hypothalamic orexin mRNA is found to be up-regulated in fasting. Orexin-A and B are coded tandemly in the same mRNA flanked by the double basic amino acid residues.

The same mRNA was isolated by another group from rat hypothalamic mRNA clone; the putative reading frames corresponding to orexin-A and B are named hypocretin based on the sequence similarity to secretin. [Proc. Natl. Acad. Sci., 95, 322 (1998)]

Newly discovered appetite-boosting peptides orexin-A and B may be useful tools to analyze the regulation mechanism of feeding behavior.

Feeding behaviour is regulated by many compounds including peptides and proteins; one of the recent topics in this field is the discovery of the appetite-suppressing protein leptin. Very recently, two homologous peptides, which stimulate food consumption, have been isolated and named orexin-A and orexin-B[Cell,92, 573 (1998)]. The name orexin is from the Greek word [orexis] for appetite. These peptides were discovered in studies carried out to determine the endogenous ligands to the orphan receptor OX1R and OX2R; the notable sequence similarity of these receptors lies in the sequence of the Y2 neuropeptide Y (NPY) receptor.

Shipping | Storage | Stability
Our product Orexin A will be shipped at room temperature. Information about product specific storage conditions can be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing by preparing aliquots.


  1. T. Sakurai, A. Amemiya, M. Ishii, I. Matsuzaki, R.M. Chemelli, H. Tanaka, S.C. Williams, J.A. Richardson, G.P. Kozlowski, S. Wilson, J.R.S. Arch, R.E. Buckingham, A.C. Haynes, S.A. Carr, R.S. Annan, D.E. McNulty, W.-S. Liu, J.A. Terrett, N.A. Elshourbagy, D.J. Bergsma and M. Yanagisawa, Cell, 92, 573 (1998) (Original)
  2. L. de Lecea, T.S. Kilduff, C. Peyron, X.-B. Gao, P.E. Foye, P.E. Danielson, C. Fukuhara, E.L.F. Battenberg, V.T. Gautvik, F.S. Bartlett II, W.N. Frankel, A.N. van den Pol, F.E. Bloom, K.M. Gautvik and J.G. Sutcliffe, Proc. Natl. Acad. Sci. USA, 95, 322 (1998) (cDNA; SAme Sequence [Hypocretin])