Nocistatin (Human)

4355-v 0.5 mg | 225.00 EUR

Met – Pro – Arg – Val – Arg – Ser – Leu – Phe – Gln – Glu – Gln – Glu – Glu – Pro – Glu – Pro – Gly – Met – Glu – Glu – Ala – Gly – Glu – Met – Glu – Gln – Lys – Gln – Leu – Gln

Synthetic Product

The purity is guaranteed to be higher than 99% by HPLC

Allodynia/Hyperalgesia-Blocking Peptide
Nociceptin Action Blocking Peptide

Nocistatin | A peptide that blocks nociceptin action is found from the nociceptin precursor

Nociceptin [Nature, 377, 532 (1995)] / Orphanin FQ [Science, 270, 792 (1995)], is an endogenous ligand for the orphan opioid-like receptor. Nociceptin induces both allodynia (pain resulting from a non-noxious stimulus to normal skin) and hyperalgesia when administered intrathecally [Brit. J. Pharmacol., 121, 401 (1997)].

Human nocistatin: Bovine nocistatin is flanked by a pair of basic residues and is a 17-residue peptide, while the human precursor lacks the corresponding amino-terminal double basic residues and may be processed enzymatically to a 30-residue peptide. This putative peptide was synthesized chemically and was found to have the same biological activities as bovine nocistatin [Br. J. Pharmacol., 124, 1016 (1998)]. The IC50 values are one order of magnitude higher than those of the bovine peptide; however, the efficacy is still high enough as an endogenous pharmacological agent. Therefore, this peptide is termed human nocistatin, which may be involved in the modulation of pain transmission in humans.

Shipping | Storage | Stability
Our product Nocistatin will be shipped at room temperature. Information about product specific storage conditions will be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing by preparing aliquots.

References:

1. T. Minami, E. Okuda-Ashitaka, Y. Nishiuchi, T. Kimura, S. Tachibana, H. Mori and S. Ito, Br. J. Pharmacol, 124, 1016 (1998) (Original; Pharmacol.)
2. C. Mollereau, M.-J. Simons, P. Soularue, F. Liners, G. Vassart, J.-C. Meunier and M. Parmentier, Proc. Natl. Acad. Sci. USA, 93, 8666 (1996) (Original; Prepronociceptin Nucleotide Seq.)