Neuromedin U (Rat)
NMU-23 (Rat)

4377-v 0.5 mg | 125.00 EUR

Tyr – Lys – Val – Asn – Glu – Tyr – Gln – Gly – Pro – Val – Ala – Pro – Ser – Gly – Gly – Phe – Phe – Leu – Phe – Arg – Pro – Arg – Asn – NH₂

Synthetic Product

The purity is guaranteed to be higher than 99% by HPLC

Food Intake Suppressor

Neuromedin U (NMU), was identified as a single entity, consisting of 23 amino acid residues (NMU-23) because of lack of the double basic site (Gly-Gly substitution for Arg-Arg). In addition to its role in smooth muscle contraction, NMU exerts some other biological activities such as increase of blood pressure, induction of ACTH release, etc. However, the specific receptor for NMU has long been unidentified. NMU itself is present in the brain as well as in the gut. Applying the recently developed technique of using the so-ca lied orphan G-protein coupled receptors, NMU has been reported to be a ligand of two structurally related receptors by several groups [reference 3 and J. Biol. Chem., 275, 20247 (2000), ibid., p. 21068, ibid., p. 29528]. One is expressed predominantly in peripheral tissue, while another is expressed in the CNS. It is especially interesting to note that in the rat brain, the second form is expressed in the paraventricular nucleus of the hypothalamus, suggesting NMU to be involved in the regulation of food intake. Actually, NMU mRNA is located abundantly in the ventromedial hypothalamic regions and its level is reduced in rats fasted for 48 h. When NMU is injected at a dose of 3 or 10 µg in rats, overnight food intake is significantly decreased and accordingly body weight is reduced^3.4). Water intake was also found to be suppressed³⁾.

References:

1. J.M. Conlon, J. Domin, L. Thim, V. DiMarzo, H.R. Morris, and S.R. Bloom, J. Neurochem., 51, 988 (1988) (Original; Primary Structure)
2. N. Minamino, K. Kangawa, M. Honzawa, and H. Matsuo, Biochem. Biophys. Res. Commun., 156, 355 (1988) (Original; Primary Structure)
3. A.D. Howard, R. Wang, S.-S. Pong, T.N. Mellin, A. Strack, X.-M. Guan, Z. Zeng, D.L. Williams, Jr., S.D. Feighner, C.N. Nunes, B. Murphy, J.N. Stair, H. Yu, Q. Jiang, M.K. Clements, C.P. Tan, K.K. McKee, D.L. Hreniuk, T.P. McDonald, K.R. Lynch, J.F. Evans, C.P. Austin, C.T. Caskey, L.H.T Van der Pleog and Q. Liu, Biochem. Biophys. Res. Commun., 277, 191 (2000) (Pharmacol.)