Guanylin (Rat, Mouse)

Pro – Asn – Thr – Cys – Glu – Ile – Cys – Ala – Tyr – Ala – Ala – Cys – Thr – Gly – Cys

Synthetic Product (disulfide bonds between Cys⁴-Cys¹² and Cys⁷-Cys¹⁵)

The purity is guaranteed to be higher than 99% by HPLC

Guanylin (Rat, Mouse) is a 15 mer endogenous intestinal Peptide. It is a potent Cyclase C Activator and plays a role in the electrolyte secretion and regulation of water.

References:

1. M.G. Currie, K.F. Fok, J. Kato, R.J. Moore, F.K. Hamra, K.L. Duffin, and C.E. Smith, Proc. Natl. Acad. Sci. USA., 89, 947 (1992) (Original; Guanylin Rat)
2. R.C. Wiegand, J. Kato and M.G. Currie, Biochem. Biophys. Res. Commun., 185, 812 (1992) (Original; Rat cDNA)
3. S. Schults, T.D. Chrisman and D.L. Garbers, . Biol. Chem., 267, 16019 (1992) (Tissue Distribution)
4. F.J. de Sauvage, S. Keshav, W.-J. Kuang, N. Gillett, W. Henzel and D.V. Goeddel, Proc. Natl. Acad. Sci. USA., 89, 9089 (1992) (Original; Guanylin Mouse cDNA)