Adrenomedullin (Rat)

4281-s 0.1 mg | 205.00 EUR

Synthetic Product (Disulfide bond between Cys¹⁴-Cys¹⁹)

Tyr – Arg – Gln – Ser – Met – Asn – Gln – Gly – Ser – Arg – Ser – Thr – Gly – Cys – Arg – Phe – Gly – Thr – Cys – Thr – Met – Gln – Lys – Leu – Ala – His – Gln – Ile – Tyr – Gln – Phe – Thr – Asp – Lys – Asp – Lys – Asp – Gly- Met – Ala – Pro – Arg – Asn – Lys – Ile – Ser – Pro – Gln – Gly – Tyr – NH₂

The purity is guaranteed to be higher than 99% by HPLC

The biological activity of this peptide is examinded by the Division of Pharmacology, Peptide Institute, Inc.

Hypotensive Peptide

Adrenomedullin (Rat) is a polypeptide amide of 50 amino acids instead of 52 amino acids for the corresponding human Adrenomedullin. It shows not only diuretic, natriuretic and vasodilatory activities, Adrenomedullin (Rat) has also some pro-apoptotic and anti-proliferative effects in mesangial cells. Dose-dependent antimicrobial activity against E. coli has been reported recently.

References:

1. J. Sakata, T. Shimokubo, K. Kitamura, S. Nakamura, K. Kangawa, H. Matsuo and T. Eto, Biochem. Biophys. Res. Commun. , 195, 921 (1993). (Original; cDNA & Biological Activity)