Fmoc-Cys(Dpm)
2329 5 g | 105.00 EUR
9-Fluorenylmethoxycarbonyl-S-diphenyl-L-cysteine
| (M.W. 509.62) | C31H27NO4S | 247595-29-5 |
Synthetic Product
Fmoc-protected cysteine derivative for regio selective disulfide construction in combination with Fmoc-Cys(Trt)
The diphenyl (Dpm) group is helpful to prevent the risk of racemization during the incorporation of the Cys residue. Fmoc-Cys(Dpm) is fully compatible with Fmoc-Cys(Trt) for regio selective disulfide construction because the Dpm group requires 60% TFA for cleavage where as the trityl group is cleaved with 10 % TFA.
References:
- M. Góngora-Benítez, L. Mendive-Tapia, I. Ramos-Tomillero, A.C. Breman, J. Tulla-Puche and F. Albericio, Org. Lett., 14, 5472(2012)
- H. Hibino, Y. Miki and Y. Nishiuchi, J. Pept. Sci., 20, 30(2014)
