Conantokin G

Conantokin G

180,00  excl. 19% VAT

Conantokin G
(Marine Snail, Conus geographus)

4265-v 0.5 mg | 180.00 EUR

Synthetic Product

Gly – Glu – Gla – Gla – Leu – Gln – Gla – Asn – Gln – Gla – Leu – Ile – Arg – Gla – Lys – Ser – Asn – NH2
(Gla: L-γ-Carboxyglutamic acid

(M.W. 2264.2) C88H138N26O44 [93438-65-4]

The purity is guaranteed to be higher than 99% by HPLC

Sleeper Peptide / N-methyl-D-Aspartate (NMDA) Receptor Antagonist

Conantokin G is a polypeptide originally isolated from the marine snail, Conus geographus. This synthetic 17 amino acid residue long peptide amide is an extremely active sleep inducing peptide (Sleeper Peptide) and a potent antagonist of N-methyl-D-aspartate (NMDA) receptor. Conantokin G is a structurally unusual peptide, because it contains a disproportionately large number of acid labile post-translational gamma-carboxyglutamic acid (Gla) residues.


  1. J.M. Mcintosch, B.M. Olivera, L.J. Cruz and W.R. Gray, J. Biol. Chem., 259, 14343 (1984) (Original)
  2. L.G. Hammerland, B.M. Olivera, and D. Yoshikami, Eur. J. Pharmacol., 226, 239 (1992) (Pharmacology of Conantokin G)
  3. Y. Nishiuchi, M. Nakao, M. Nakata, T. Kimura and S. Sakakibara, Int. J. Pept. Protein Res., 42, 533 (1993) (Chem. Synthesis)